Prevalence of Cholelithiasis Among Nigerians: A Prospective Sonographic Study In A Tertiary Center In Sokoto, Northwest Nigeria
DOI:
https://doi.org/10.70411/MJHAS.2.1.2025186Keywords:
Cholelithiasis, Gallstones, Nigerians, Native black populationAbstract
Gallstone is a common and major biliary disease of modern society and is thought to be rare among Asians and the Black population. However, this narrative may also be changing with the increasing westernization of the African diet and changing lifestyle. We aimed to evaluate the sonographic prevalence of gallstones in Sokoto, North-west Nigeria. This was a descriptive, prospective study. Socio-demographic, clinical and sonographic data of all consenting patients presenting to the radiology department of Usmanu Danfodiyo University Teaching Hospital (UDUTH) Sokoto for an abdominal ultrasound between April 2024 and September 2024 were prospectively collected using a structured proforma. Statistical significance was set at a p-value of <0.05. There were 1456 who met the inclusion criteria and thus participated in the study. The majority (sixty-nine per cent) were females, the mean age was 38.3±15.0 years, and forty-nine per cent were above 40 years. The majority had a normal body mass index (BMI). The number of patients with cholelithiasis was 52, giving a prevalence of 3.57%. Prevalence among females, 4.5%, was significantly higher than that among males, 1.6% (p=0.001). Likewise, prevalence was significantly higher among overweight (6.5%) and obese (8.2%) patients than in standard (1.6%) and underweight patients (0.9%). The prevalence was observed to rise with increasing age, higher in diabetic patients and those with a family history of gallstones; however, these observed differences were not statistically significant. Cholelithiasis remains a relatively uncommon condition in our setting. Female gender and obesity significantly increased the odds of developing cholelithiasis.
References
Attili, A. F., De Santis, A., Attili, F., Roda, E., Festi, D., & Carulli, N. (2005). Prevalence of gallstone disease in first-degree relatives of patients with cholelithiasis. World journal of gastroenterology: WJG, 11(41), 6508.
Bagi Abdel, M., Arabi, M., Abdel Rahim, B., Al Asma, A., Gibril, M., & Mubarak, M. (1991). Prevalence of gallbladder disease in Sudan: first sonographic field study in adult population. Gastroenterology, 100, A307.
Berci, G. (2004). Historical overview of surgical treatment of biliary stone disease. In Laparoscopic surgery of the abdomen (pp. 139-142). Springer.
Bertolotti, M., Abate, N., Bertolotti, S., Loria, P., Concari, M., Messora, R., Carubbi, F., Pinetti, A., & Carulli, N. (1993). Effect of aging on cholesterol 7 alpha-hydroxylation in humans. Journal of lipid research, 34(6), 1001-1007.
Cao, A. M., & Eslick, G. D. (2018). Epidemiology and pathogenesis of gallstones. The Management of Gallstone Disease: A Practical and Evidence-Based Approach, 53-66.
Caroli-Bosc, F.-X., Deveau, C., Harris, A., Delabre, B., Peten, E. P., Hastier, P., Sgro, E., Caroli-Bosc, C., Stoia, M., & Demarquay, J.-F. (1999). Prevalence of cholelithiasis (results of an epidemiologic investigation in vidauban, southeast france). Digestive diseases and sciences, 44, 1322-1329.
Chen, C. H., Huang, M. H., Yang, J. C., Nien, C. K., Etheredge, G. D., Yang, C. C., Yeh, Y. H., Wu, H. S., Chou, D. A., & Yueh, S. K. (2006). Prevalence and risk factors of gallstone disease in an adult population of Taiwan: an epidemiological survey. Journal of gastroenterology and hepatology, 21(11), 1737-1743.
Einarsson, K., Nilsell, K., Leijd, B., & Angelin, B. (1985). Influence of age on secretion of cholesterol and synthesis of bile acids by the liver. New England Journal of Medicine, 313(5), 277-282.
Everhart, J. E., Khare, M., Hill, M., & Maurer, K. R. (1999). Prevalence and ethnic differences in gallbladder disease in the United States. Gastroenterology, 117(3), 632-639.
Everhart, J. E., Yeh, F., Lee, E. T., Hill, M. C., Fabsitz, R., Howard, B. V., & Welty, T. K. (2002). Prevalence of gallbladder disease in American Indian populations: findings from the Strong Heart Study. Hepatology, 35(6), 1507-1512.
Eze, C. U., Ezugwu, E. E., & Ohagwu, C. C. (2017). Prevalence of cholelithiasis among Igbo adult subjects in Nnewi, Southeast Nigeria: A community-based sonographic study. Journal of Diagnostic Medical Sonography, 33(2), 83-90.
Gyedu, A., Adae-Aboagye, K., & Badu-Peprah, A. (2015). Prevalence of cholelithiasis among persons undergoing abdominal ultrasound at the Komfo Anokye Teaching Hospital, Kumasi, Ghana. African health sciences, 15(1), 246-252.
Kratzer, W., Mason, R. A., & Kächele, V. (1999). Prevalence of gallstones in sonographic surveys worldwide. Journal of clinical ultrasound, 27(1), 1-7.
Marschall, H. U., & Einarsson, C. (2007). Gallstone disease. Journal of internal medicine, 261(6), 529-542.
Mbogori, T., & Mucherah, W. (2019). Nutrition transition in Africa: consequences and opportunities. Global Journal of Transformative Education, 1(1), 5-10.
Njeze, G. E. (2013). Gallstones. Nigerian Journal of surgery, 19(2), 49-55.
Rahman, G. A. (2005). Cholelithiasis and cholecystitis: changing prevalence in an African community. Journal of the National Medical Association, 97(11), 1534.
Ratheesh, R., Ulrich, M. T., Ghozy, S., Al-Jaboori, M., & Nayak, S. S. (2023). The association between diabetes and gallstones: a nationwide population-based cohort study. Gastroenterology Review/Przegląd Gastroenterologiczny, 18(3), 292-299.
Safer, L., Bdioui, F., Braham, A., Salem, B., Soltani, M. S., Bchir, A., & Saffar, H. (2000). Epidemiology of cholelithiasis in central Tunisia. Prevalence and associated factors in a nonselected population. Gastroentérologie clinique et biologique, 24(10), 883-887.
Salari, N., Hasheminezhad, R., Heidarisharaf, P., Khaleghi, A. A., Azizi, A. H., Shohaimi, S., & Mohammadi, M. (2023). The global prevalence of gallstones in pregnancy: A systematic review and meta-analysis. European Journal of Obstetrics & Gynecology and Reproductive Biology: X, 19, 100237.
Salinas, G., Velásquez, C., Saavedra, L., Ramírez, E., Angulo, H., Tamayo, J., Orellana, A., Huivin, Z., Valdivia, C., & Rodríguez, W. (2004). Prevalence and risk factors for gallstone disease. Surgical Laparoscopy Endoscopy & Percutaneous Techniques, 14(5), 250-253.
Sampliner, R. E., Bennett, P. H., Comess, L. J., Rose, F. A., & Burch, T. A. (1970). Gallbladder disease in Pima Indians: demonstration of high prevalence and early onset by cholecystography. New England Journal of Medicine, 283(25), 1358-1364.
Schwesinger, W. H., Kurtin, W. E., Page, C. P., Stewart, R. M., & Johnson, R. (1999). Soluble dietary fiber protects against cholesterol gallstone formation. The American journal of surgery, 177(4), 307-310.
Stinton, L. M., & Shaffer, E. A. (2012). Epidemiology of gallbladder disease: cholelithiasis and cancer. Gut and liver, 6(2), 172.
Walcher, T., Haenle, M. M., Kron, M., Hay, B., Mason, R. A., von Schmiesing, A. F. A., Imhof, A., Koenig, W., Kern, P., & Boehm, B. O. (2005). Pregnancy is not a risk factor for gallstone disease: results of a randomly selected population sample. World journal of gastroenterology, 11(43), 6800.
Walker, A., Segal, I., Posner, R., Shein, H., Tsotetsi, N., & Walker, A. (1989). Prevalence of gallstones in elderly black women in Soweto, Johannesburg, as assessed by ultrasound. American Journal of Gastroenterology (Springer Nature), 84(11).
Wiegand, H. (1968). Kish, L.: Survey Sampling. John Wiley & Sons, Inc., New York, London 1965, IX+ 643 S., 31 Abb., 56 Tab., Preis 83 s. In: Wiley Online Library.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Modern Journal of Health and Applied Sciences

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
The users are free to:
- Share — copy and redistribute the material in any medium or format.
- Adapt — remix, transform, and build upon the material.
The licensor cannot revoke these freedoms as long as you follow the license terms.






